2010

P450cam the Movie

How does P450cam open and close its active site? Here is an experimentally derived animation of 21 crystal structures showing a proposed trajectory for opening of the substrate binding channel

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2010

A protein based model for nitric oxide synthase

A recent paper describes how a peroxidase was used to construct a model for the reactions catalyzed by the second cycle of nitric oxide synthase.

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2010

P450cam displays an open personality

We showed that the well known enzyme P450cam, which has long been thought to have a closed and static active site, visits an open conformation in the absence of substrate.

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2010

A mitochondrial P450 that metabolizes vitamin D

We have solved the first structure of a P450 from mitochondria. This enzyme is an important cancer drug target because it is involved in the metabolism of vitamin D.

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2009

Congratulations to Edith (Phoebe) Glazer as she starts in her new position as Assistant Professor of Chemistry at University of Kentucky

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2009

Replacement of a electron transfer pathway in a protein with a peptide

We replaced the segment of the protein backbone that is proposed to serve as the electron transfer pathway in yeast peroxidase with an artificial peptide.

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2009

Axial ligand engineering in a heme binding nitrophorin

We have characterized the stucture and ligand binding properties of a mutant of nitrophorin 1 in which the axial ligand is replaced by cysteine

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2009

Pterin based molecular probes for the active site of NOS

Designed syntetic analogs of the pterin substrate linked to ruthenium photosensitizers have been designed to bind the active site of nitric oxide synthase

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2007

Stefan Vetter begins new position as Assistant Professor of Chemistry at Florida Atlantic University

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